49ers VS Saints Odds: Who Is Favored To Win?
Check out the different betting odds for the 49ers second game of the year 👇
| 🏈 Spread | -7 |
| 📈 Moneyline | -360 |
| 📊 Over/Under | 44.5 |
| ✅ Last Verified: | July 14, 2025 |
49ers Chances To Win vs Saints
San Francisco enters this matchup as a 7-point favorite on the road. The Saints, under new head coach Kellen Moore, are in a rebuilding phase after a disappointing 5–12 season. Moore, previously the offensive coordinator for the Philadelphia Eagles, led them to a Super Bowl victory and now aims to revitalize New Orleans' offense, despite missing a number of key pieces on both sides of the football. The 49ers, who are looking to bounce back from a 6-11 campaign last season, are hopeful that quarterback Brock Purdy, running back Christian McCaffrey, and their offensive weapons can bring them back to the playoffs; a place they have been often under head coach Kyle Shanahan.
How The 49ers Win vs Saints
San Francisco’s victory will hinge on dominating time of possession and converting red-zone opportunities. When the team posts a third-down conversion rate above 50 percent and maintains a balanced run-pass attack, they will force the Saints to play catch-up. Key playmakers like Brock Purdy and tight end George Kittle need to consistently perform, while the running back group must open up play action by breaking tackles. Limiting turnovers and exploiting mismatches on the defensive line will help control the game’s tempo in a game they should win.
- Strength: Balanced offense with a dynamic rushing attack and efficient passing game.
- Weakness: Potential vulnerability in pass protection, especially with the loss of key offensive linemen this offseason.
How The Saints Win vs 49ers
New Orleans' path to victory involves exploiting the 49ers' defensive adjustments and establishing a strong running game. Alvin Kamara remains a pivotal figure in the backfield, and the Saints will look to capitalize on any lapses in the 49ers' defensive schemes. Moore's offensive acumen as a former offensive coordinator will be crucial in orchestrating a game plan that fits with the pieces of a Saints roster that is ranked in the lower third of the league, including figuring out a way to make sure quarterback Tyler Shough is prepared.
- Strength: Strong running game led by Kamara and innovative offensive schemes that worked well in Kellen Moore's previous stops.
- Weakness: Inexperienced quarterback play and potential growing pains in a new system.
Quick Facts on 49ers Vs Saints
Injuries for San Francisco 49ers Vs New Orleans Saints
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Author
Dan Thompson is a Lead Betting Analyst and NFL Writer for BetCanada. Dan's unique experience makes him the perfect fit for you to know the latest on popular NFL teams in Canada.