Seahawks vs 49ers Odds: Who Is Favored To Win?
Below are the different betting odds for the Seahawks first game of the year 👇
| 🏈 Spread | +1.5 |
| 📈 Moneyline | +105 |
| 📊 Over/Under | 49.5 |
| ✅ Last Verified: | August 6, 2025 |
Seahawks Chances To Win vs 49ers
The Seattle Seahawks open as about a 1.5-point underdog at home, with moneyline odds near +105 and San Francisco’s −125 and a 45.5 over/under. The franchise has won six straight in the series, including a Week 1 upset in 2024. Darnold must avoid turnovers, and they must win the run game and time-of-possession battle to stay in this game and fight for the upset.
How The Seahawks Win vs 49ers
Sam Darnold must build on his 4,319-yard, 35-touchdown Pro Bowl season from last season with the Vikings and improve his accuracy under pressure. Seattle’s defense must limit explosive plays and force three‑and‑outs early to tilt the field position. A strong ground game from Kenneth Walker and third-down efficiency will help control the clock and pace.
- Strength: Fresh QB energy in Darnold and a motivated defense keyed on disruption.
- Weakness: Offensive line concerns and Darnold’s struggles under duress could be exploited.
How The 49ers Win vs Seahawks
The 49ers win this game by leaning on their top-five offense, which averages over 376 yards per game and ranks fourth in scoring. Their defense allows just 19.4 points per game and has held opponents to a 38% third-down conversion rate. If they control the pace with Christian McCaffrey’s 100+ total yards per game and pressure Sam Darnold into mistakes, Seattle will struggle to keep up. Their biggest weakness from last season, run defense, has been improved by offseason upgrades, but it’s still the matchup Seattle must try to exploit.
- Strength: Ball-control offense and suffocating defensive front.
- Weakness: If the game turns into a shootout early, Seattle’s big-play potential may challenge them.
Quick Facts on Seahawks Vs 49ers
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Author
Brandon Justice has nearly a decade of experience covering sports, primarily working in college football, college basketball, NFL and MLB. Brandon provides a detailed analysis of the latest iGaming & sports betting trends with a wealth of experience, including writing for The Action Network & Rivals.com.