Seattle Seahawks Vs Arizona Cardinals Week 4 Odds

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Key Takeaways:

  • 🔥 Both teams will be coming into this matchup on a short week.
  • 📈 Seattle won the first matchup last year 16-6 at home before Arizona got revenge with a late-season victory, making this early divisional clash crucial for NFC West standings.
  • 📅 This Thursday Night Football matchup marks the Cardinals' first TNF game since 2022, and historically they're 0-3 on Thursday nights against Seattle (losses in 2013, 2017, and 2020)

Get the full breakdown on the Seattle Seahawks postseason odds

Seahawks vs Cardinals Odds: Who Is Favored To Win?

Below are the betting odds for the Seahawks fourth game of the year 👇

🏈 Spread2.5
📈 Moneyline+115
📊 Over/Under46.5
Last Verified:August 6, 2025

Seahawks Chances To Win vs Cardinals

Seattle enters as a 2.5-point favorite in Week 4 with a 52% implied win probability, according to oddsmakers. Last season, Seattle swept both games against Arizona, winning 30–18 and 16–6. For the Seahawks to stay competitive, they must replicate that defensive dominance, limit turnovers, and protect Sam Darnold from Arizona’s emerging pass rush, while trying to keep Kyler Murray at bay.

How The Seahawks Win vs Cardinals

Seattle will win by completely controlling the trenches and the turnover margin. Their defense, which recorded 45 sacks and 14 forced fumbles in 2024, must pressure Kyler Murray and prevent explosive plays. Offensively, they must lean on Kenneth Walker’s rushing efficiency, convert on third downs, while allowing Sam Darnold time to connect with wide receivers Cooper Kupp and Jaxon Smith-Njigba. Seattle will need to avoid sacks, something Darnold struggled with as a member of the Vikings, and they must avoid costly, drive-killing penalties. 

  • Strength: Elite defensive pressure and solid offensive playmakers that should match up well against the Cardinals' defense.
  • Weakness: A vulnerable offensive line that has struggled with pass protection in the past.

How The Cardinals Win vs Seahawks

Arizona wins by owning the line of scrimmage and maximizing downfield threats. Their offseason additions of Josh Sweat and rookies Walter Nolen and Jordan Burch bolster a defense expected to generate pressure, something that Darnold has often struggled with throughout his career. Offensively, Murray’s dual-threat style demands respect from any team it competes against, and if Seattle’s defense prioritizes his rushing, he can beat them deep. 

  • Strength: Reinforced pass rush combined with Murray’s explosive play-making ability.
  • Weakness: Secondary depth is thin, losing veteran Sean Murphy‑Bunting for the season and relying on developing cornerbacks may leave them exposed against Seattle’s deep threats.

Quick Facts on Seahawks Vs Cardinals

Injuries for Seattle Seahawks Vs Arizona Cardinals

Lineups for Seahawks vs Cardinals in Week 4

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Brandon Justice

Brandon Justice has nearly a decade of experience covering sports, primarily working in college football, college basketball, NFL and MLB. Brandon provides a detailed analysis of the latest iGaming & sports betting trends with a wealth of experience, including writing for The Action Network & Rivals.com.