Seahawks vs Cardinals Odds: Who Is Favored To Win?
Below are the betting odds for the Seahawks fourth game of the year 👇
| 🏈 Spread | 2.5 |
| 📈 Moneyline | +115 |
| 📊 Over/Under | 46.5 |
| ✅ Last Verified: | October 28, 2025 |
Seahawks Chances To Win vs Cardinals
Seattle enters as a 2.5-point favorite in Week 10 with a 52% implied win probability, according to oddsmakers. Last season, Seattle swept both games against Arizona, winning 30–18 and 16–6. For the Seahawks to stay competitive, they must replicate that defensive dominance, limit turnovers, and protect Sam Darnold from Arizona’s emerging pass rush, while trying to keep Kyler Murray at bay.
How The Seahawks Win vs Cardinals
Seattle will win by completely controlling the trenches and the turnover margin. Their defense, which recorded 45 sacks and 14 forced fumbles in 2024, must pressure Kyler Murray and prevent explosive plays. Offensively, they must lean on Kenneth Walker’s rushing efficiency, convert on third downs, while allowing Sam Darnold time to connect with wide receivers Cooper Kupp and Jaxon Smith-Njigba. Seattle will need to avoid sacks, something Darnold struggled with as a member of the Vikings, and they must avoid costly, drive-killing penalties.
- Strength: Elite defensive pressure and solid offensive playmakers that should match up well against the Cardinals' defense.
- Weakness: A vulnerable offensive line that has struggled with pass protection in the past.
How The Cardinals Win vs Seahawks
Arizona wins by owning the line of scrimmage and maximizing downfield threats. Their offseason additions of Josh Sweat and rookies Walter Nolen and Jordan Burch bolster a defense expected to generate pressure, something that Darnold has often struggled with throughout his career. Offensively, Murray’s dual-threat style demands respect from any team it competes against, and if Seattle’s defense prioritizes his rushing, he can beat them deep.
- Strength: Reinforced pass rush combined with Murray’s explosive play-making ability.
- Weakness: Secondary depth is thin, losing veteran Sean Murphy‑Bunting for the season and relying on developing cornerbacks may leave them exposed against Seattle’s deep threats.
Quick Facts on Seahawks Vs Cardinals
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Author
Brandon Justice has nearly a decade of experience covering sports, primarily working in college football, college basketball, NFL and MLB. Brandon provides a detailed analysis of the latest iGaming & sports betting trends with a wealth of experience, including writing for The Action Network & Rivals.com.